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Dolutegravir sodium

CAS No. 1051375-19-9

Dolutegravir sodium ( GSK-1349572A )

Catalog No. M10249 CAS No. 1051375-19-9

Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dolutegravir sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
  • Description
    Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.HIV Infection Approved
  • Synonyms
    GSK-1349572A
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIVintegrase
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    1051375-19-9
  • Formula Weight
    441.36
  • Molecular Formula
    C20H18F2N3NaO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 4.4 mg/mL; DMSO: < 12.6 mg/mL
  • SMILES
    C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]
  • Chemical Name
    2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, sodium salt (1:1), (4R,12aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
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