Dolutegravir sodium
CAS No. 1051375-19-9
Dolutegravir sodium ( GSK-1349572A )
Catalog No. M10249 CAS No. 1051375-19-9
Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 40 | In Stock |
|
5MG | 65 | In Stock |
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10MG | 102 | In Stock |
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25MG | 173 | In Stock |
|
50MG | 260 | In Stock |
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100MG | 372 | In Stock |
|
500MG | 849 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameDolutegravir sodium
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NoteResearch use only, not for human use.
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Brief DescriptionDolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
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DescriptionDolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.HIV Infection Approved
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SynonymsGSK-1349572A
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PathwayMicrobiology/Virology
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TargetHIV
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RecptorHIVintegrase
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Research AreaInfection
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IndicationHIV Infection
Chemical Information
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CAS Number1051375-19-9
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Formula Weight441.36
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Molecular FormulaC20H18F2N3NaO5
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 4.4 mg/mL; DMSO: < 12.6 mg/mL
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SMILESC[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]
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Chemical Name2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, sodium salt (1:1), (4R,12aS)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
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