Dolutegravir sodium

CAS No. 1051375-19-9

Dolutegravir sodium ( GSK-1349572A )

Catalog No. M10249 CAS No. 1051375-19-9

Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 40 In Stock
5MG 65 In Stock
10MG 102 In Stock
25MG 173 In Stock
50MG 260 In Stock
100MG 372 In Stock
500MG 849 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Dolutegravir sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM.
  • Description
    Dolutegravir sodium (GSK-1349572A) is a potent, next-generation HIV integrase (IN) inhibitor, inhibits HIV-1 integrase-catalyzed strand transfer with IC50 of 2.7 nM; inhibits HIV-1 replication in PBMCs, MT-4 cells and in the PHIV assay with EC50 of 0.51, 0.71 and 2.2 nM, respectively; demonstrates activity against site-directed molecular clones containing the raltegravir-resistant signature mutations Y143R, Q148K, N155H, and G140S/Q148H; exhibits excellent anti-HIV activity in combination with representative approved antiretroviral agents in vivo.HIV Infection Approved
  • Synonyms
    GSK-1349572A
  • Pathway
    Microbiology/Virology
  • Target
    HIV
  • Recptor
    HIVintegrase
  • Research Area
    Infection
  • Indication
    HIV Infection

Chemical Information

  • CAS Number
    1051375-19-9
  • Formula Weight
    441.36
  • Molecular Formula
    C20H18F2N3NaO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 4.4 mg/mL; DMSO: < 12.6 mg/mL
  • SMILES
    C[C@@H]1CCO[C@@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)[O-].[Na+]
  • Chemical Name
    2H-Pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, N-[(2,4-difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-hydroxy-4-methyl-6,8-dioxo-, sodium salt (1:1), (4R,12aS)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kobayashi M, et al. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21.
2. Garrido C, et al. Antiviral Res. 2011 Jun;90(3):164-7.
3. Hightower KE, et al. Antimicrob Agents Chemother. 2011 Oct;55(10):4552-9.
4. Hare S, et al. Mol Pharmacol. 2011 Oct;80(4):565-72.
molnova catalog
related products
  • Nevirapine

    A potent and specific non-nucleoside inhibitor (NNRTI) of HIV-1 reverse transcriptase with Ki of 0.2 uM.

  • Saquinavir mesylate

    Apotent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.

  • Vipirinin

    A coumarin-based HIV-1 viral protein R (Vpr) inhibitor, inhibits Vpr-dependent viral infection of human macrophages.